My dad is dealing with prostate cancer and metastatic i.e. Spread to bones. He is heart and diabetic patient as well. He had undergone surgery to remove testicles almost year back. Psa test shown low reading - 0.140 after surgery but start increasing gradually since then. Now psa stands at 18 and just had 2nd pet scan. Doctor compared both pet scans (6 months gap) before and after surgery and did not alarm anything new. No bone pain as such currently. Based on doctor prescription he stated zoledronic acid injection on monthly basis. 2 injections so far. He currently takes bicalutamide (50 mg) along with other calcium and vitamin d supplement here are the 2 major issues I need help1. After zoledronic acid injection. He got light fever for a week and nausea. His psa score was very low after surgery but gradually increasing in recent months now 18. He is taking bicalutamide (50 mg) (1 tablet daily) since november 2022. What are treatment options to treat the rising psa. I can share the pet scan and other reports. I am looking for a senior doctor opinion and follow up appointment. No homeopathic doctors please.